Studie zur Vorbeugung von
Darmpolypen mit Grüntee-Extrakt

Interactions

The potential of EGCG to induce drug-drug interactions by the inhibition of major human cytochrome P450 isoenzymes has been studied in vitro using isoform-selective probe substrates for the major human CYP450 isoforms involved in drug-metabolism (CYP1A2, 2C9, 2C19, 2D6 and 3A4) [32]. Based on these in vitro results, no significant interactions are expected in man for EGCG with concomitantly administered compounds mainly metabolized by CYP1A2, CY2C9, CYP2C19, CYP2D6 and CYP3A4. Interactions via inhibition of transporters such as P glycoprotein or Multidrug Resistance Protein (MRP) by EGCG is possible, but has not been reported so far.

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